Outside of some very niche scenarios, does this usecase even exist? Certainly nothing running a javascript enabled browser, electron app, or in general any VM of any sort qualifies.
All the VMs run on my employer's servers are running code we trust. None of them run arbitrary code from some third party, because we're not a cloud provider, nor are they used to browse the web. I don't want to slow them down to mitigate vulnerabilities that just aren't a serious risk or even applicable.
Sure. I’m comfortable describing HPC and on-premises fully trusted computing (another response) as “very niche scenarios” though (compared to the much much much larger markets of large cloud farms on the server side, and consumer devices), to the point where I have to wonder whether or not it’s worth it for CPU vendors to cater specific SKUs to them without the silicon mitigations.